Description
Indication:
Fever, headache, toothache, earache, bodyache, myalgia, dysmenorrhoea, neuralgia and sprains. Colic pain, back pain, chronic pain of cancer, inflammatory pain, and post-vaccination pain and fever of children. Rheumatism and osteoarthriticMedicine pain & stiffness of joints in fingers, hips, knees, wrists, elbows, feet, ankles and top & bottom of the spine.
IV Infusion: Short-term treatment of moderate pain, especially following surgery. And for the short-term treatment of fever, when administration by intravenous route is clinically justified.
Uses of Ace 500
- Pain relief
- Fever
Side effects of Ace 500
Common
- No common side effects see
How to use Ace 500
Take 500mg medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ace 500 is to be taken with food.
How Ace 500 works
Ace 500 is an analgesic (pain reliever) and anti-pyretic (fever reducer). It works by blocking the release of certain chemical messengers that cause pain and fever. Ace 500 is an analgesic (pain reliever) and anti-pyretic (fever reducer). It works by blocking the release of certain chemical messengers that cause pain and fever.
What if you forget to take Ace 500?
If you miss a dose of Ace 500, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Quick Tips
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Ace 500 should be taken with food or milk to prevent upset stomach.
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Take it as per the dose and duration prescribed by your doctor. Long term use may lead to serious complications such as stomach bleeding and kidney problems.
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Do not take indigestion remedies (antacids) within two hours of taking Ace 500.
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Avoid consuming alcohol while taking this medicine as it can increase your risk of stomach problems.
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Inform your doctor if you have liver disease as your dose may need to be adjusted.
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Your doctor may regularly monitor your kidney function, liver function and levels of blood components if you are taking this medicine for long-term treatment.
Brief DescriptionIndicationFever, Mild to moderate pain, osteoarthritis, rheumatoid arthritis, chronic low back pain, Renal stone pain, neuropathic pain, toothache, migraine, postoperative mild to moderate pain.AdministrationMay be taken with or without food.Adult DoseOral Mild to moderate pain and fever Tablet Adult: 1 – 2 tablets every 4 to 6 hours up to a maximum of 4 g (8 tablets) daily Extended Release (XR) Tablet Adults: 2 tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours). Syrup/Suspension: Adults: 4-8 Measuring spoonful 3-4 times daily; Rectal Suppository Adults: 500 mg-1 g every 4-6 hours to a maximum of 4 g daily.
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Child Dose
Oral Mild to moderate pain and fever Tablet Children (6 – 12 years) : 1/2 to 1 tablet 3 to 4 times daily Extended Release (XR) Tablet Children over 12 years: 2 tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours). Syrup Mild to moderate pain and fever Children: 3 months – <1 year : 60 – 120 mg (1/2 – 1 measuring spoonful), 1 – 5 years : 1 – 2 measuring spoonful 6 – 12 years : 2 – 4 measuring spoonful Children: 2 months: 60 mg (1/2 measuring spoonful) for post immunization pyrexia; Paediatric Drops Mild to moderate pain and fever Children Up to 3 months: 0.5 ml (40 mg) 4 to 11 months: 1.0 ml (80 mg) 1 to <2 years: 1.5 ml (120 mg) 2 to 3 years: 2 ml (160mg) 4 to 5 years: 3 ml (240 mg) Dose can be repeated, every 4 hours. Rectal Mild to moderate pain and fever Suppository Children: 3 months-<1 year: 60-125 mg 1-<5 years: 125-250 mg 5-12 years: 250-500 mg These doses may be repeated every 4-6 hours as necessary (maximum 4 doses in 24 hours). Children over 12 years: 500 mg-1 g every 4-6 hours to a maximum of 4 g daily. Post-immunisation pyrexia Child: 2-3 mth 60 mg. If necessary, a 2nd dose may be given after 4-6 hr.
Contraindication
Hypersensitivity.
Mode of Action
Paracetamol exhibits analgesic action by peripheral blockage of pain impulse generation. It produces antipyresis by inhibiting the hypothalamic heat-regulating centre. Its weak anti-inflammatory activity is related to inhibition of prostaglandin synthesis in the CNS.
Precaution
Patient w/ chronic alcoholism, known G6PD deficiency, severe hypovolaemia, chronic malnutrition. Renal and hepatic impairment. Pregnancy and lactation. Monitoring Parameters Monitor serum paracetamol levels esp when acute overdosage is suspected and w/ long-term use.
Side Effect
Thrombocytopenia, leucopenia, pancytopenia, neutropenia, agranulocytosis, pain and burning sensation at inj site. Rarely, hypotension and tachycardia. Potentially Fatal: Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalised exanthematous pustulosis, acute renal tubular necrosis and hepatotoxicity.
Interaction
May reduce serum levels w/ anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin and other coumarins w/ prolonged use. Accelerated absorption w/ metoclopramide and domperidone. May increase serum levels w/ probenecid. May increase serum levels of chloramphenicol. May reduce absorption w/ colestyramine w/in 1 hr of admin. May cause severe hypothermia w/ phenothiazine.
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