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Acitrin Syrup

Original price was: 30.10৳ .Current price is: 27.09৳ .

Cetirizine Hydrochloride 5 mg/5 ml
ACI Limited

60 ml bottle: ৳ 30.09
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Description

Indications

Acitrin is indicated for the relief of symptoms associated with seasonal & perennial allergic rhinitis. It is also indicated for the treatment of the uncomplicated skin manifestations of chronic idiopathic urticaria and allergen induced asthma.
* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন‘

Pharmacology

Cetirizine Hydrochloride is a potent H1 receptor antagonist without any significant anticholinergic and antiserotonic effects. At pharmacologically active dose levels, it has almost no drowsiness effect and does not cause behavioral changes. It inhibits the histamine-mediated early phase of the allergic reaction and also reduces the migration of inflammatory cells and the release of mediators associated with the late phase of the allergic reaction.

Pharmacokinetics: Cetirizine 10 mg achieves peak plasma concentrations of 257 mcg/L within one hour of administration (980 mcg/L in children). Food does not affect the extent of absorption, but it may slightly reduce the rate. Peak blood levels 0.3 micrograms/ml are reached between thirty & sixty minutes after administration of 10 mg dose of Cetirizine. Its plasma half-life is approximately 11 hours. Absorption is very consistent from one subject to the next. Its renal clearance is 30 ml/minute and the excretion half-life is approximately nine hours.

Dosage & Administration

Cetirizine oral dosage form:

  • Adults and Children 6 years and older: 1 tablet or 2 teaspoonfuls daily (or 1 teaspoonful twice daily).
  • Children 2-6 years: 1 teaspoonful once daily or 1/2 teaspoonful twice daily.
  • Children 6 months to 2 years : 1/2 teaspoonful once daily. The dose in children 12-23 months of age can be increased to a maximum dose as 1/2 teaspoonful every 12 hours.

Cetirizine injectable dosage form: Cetirizine is a single use injectable product for intravenous administration only. The recommended dosage regimen is once every 24 hours as needed for treatment of acute urticaria. Administer Cetirizine as an intravenous push over a period of 1 to 2 minutes. Cetirizine is not recommended in pediatric patients less than 6 years of age with impaired renal or hepatic function.

  • Adults and adolescents 12 years of age and older: The recommended dosage is 10 mg administered by intravenous injection.
  • Children 6 to 11 years of age: The recommended dosage is 5 mg or 10 mg depending on symptom severity administered by intravenous injection.
  • Children 6 months to 5 years of age: The recommended dosage is 2.5 mg administered by intravenous injection.
* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন‘

Interaction

No clinically significant drug interactions have been found with Theophylline, Azithromycin, Pseudoephedrine, Ketoconazole or Erythromycin and with other drugs.

Contraindications

It is contraindicated in patients with a history of hypersensitivity to Cetirizine or hydroxyzine.

Side Effects

The most common side effects that occurred more frequently on Acitrin is somnolence.

Pregnancy & Lactation

US FDA Pregnancy Category of Cetirizine Hydrochloride is B. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Cetirizine Hydrochloride has been shown to be excreted in human milk. So, caution should be exercised when Cetirizine Hydrochloride is administered to a nursing woman.

Precautions & Warnings

Caution should be exercised when driving a car or operating a heavy machinery.

Use in Special Populations

Hepatic or renal insufficiency: In patients with mild to moderate hepatic and renal impairment, total body clearance of Acitrin is reduced and AUC and half-life increased by about 2 to 3 fold. Clearance is reduced in proportion to the decline in creatinine clearance. Plasma levels are unaffected by hemodialysis. The plasma elimination half-life in dialysis patients is approximately 20 hours and the plasma AUC is increased by about threefold.

Pediatric Use: The safety of Acitrin has been demonstrated in pediatric patients aged 6 months to 5 years.

Elderly use: The clearance of Acitrin is reduced in elderly patients, but only in proportion to the decrease in creatinine clearance.

Therapeutic Class

Sedating Anti-histamine

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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